Fevipiprant

Fevipiprant

CAT N°: 20263
Price:

From 85.00 72.25

Fevipiprant is a DP2/CRTH2 antagonist (Ki = 1.05 nM).{32112} It reduces shape change of eosinophils induced by prostaglandin D2 (PGD2; Item No. 12010) with IC50 values of 0.4 and 0.44 nM for isolated human eosinophils and human whole blood, respectively. Fevipiprant inhibits PGD2-induced release of IL-5 and IL-13 in isolated human CD4+ Th2 cells (IC50s = 2.56 and 1.4 nM, respectively). It reduces the number of eosinophils in bronchoalveolar lavage fluid (BALF) in a mouse model of asthma (ED50 = ~1 mg/kg).{57949}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-methyl-1-[[4-(methylsulfonyl)-2-(trifluoromethyl)phenyl]methyl]-1 H -pyrrolo[2,3b]pyridine-3-acetic acid
  • Correlated keywords
    • DP CRTH interleukin IL5 IL13 PGD CD-4 Th-2 NVPQAW039 QAW-039
  • Product Overview:
    Fevipiprant is a DP2/CRTH2 antagonist (Ki = 1.05 nM).{32112} It reduces shape change of eosinophils induced by prostaglandin D2 (PGD2; Item No. 12010) with IC50 values of 0.4 and 0.44 nM for isolated human eosinophils and human whole blood, respectively. Fevipiprant inhibits PGD2-induced release of IL-5 and IL-13 in isolated human CD4+ Th2 cells (IC50s = 2.56 and 1.4 nM, respectively). It reduces the number of eosinophils in bronchoalveolar lavage fluid (BALF) in a mouse model of asthma (ED50 = ~1 mg/kg).{57949}

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