KT172

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KT172

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Cat No: 19112

Biochemicals - Small Molecule Inhibitors

KT172 is a non-selective inhibitor of diacylglycerol lipase α (DAGLα) and DAGLβ.{30430} It inhibits DAGL-mediated hydrolysis of 1-stearoyl-2-arachidonoylglycerol (Item No. 10008650) in HEK293T cell membranes expressing recombinant DAGLα or DAGLβ (IC50...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

[4-(2'-methoxy[1,1'-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl][2-(phenylmethyl)-1-piperidinyl]-methanone

Correlated keywords:

KT-172 nonselective DAGL-? ? HEK-293T 293-T ABHD-6 PGD PGE-2

Product Overview:
KT172 is a non-selective inhibitor of diacylglycerol lipase α (DAGLα) and DAGLβ.{30430} It inhibits DAGL-mediated hydrolysis of 1-stearoyl-2-arachidonoylglycerol (Item No. 10008650) in HEK293T cell membranes expressing recombinant DAGLα or DAGLβ (IC50s = 140 and 60 nM, respectively). KT172 also inhibits α/β-hydrolase 6 (ABHD6; IC50 = 5 nM) and weakly inhibits monoacylglycerol lipase (MAGL; IC50 = 5,000 nM) in a panel of 47 mouse serine hydrolases. It restores nicotine-stimulated GABA release in isolated ventral tegmental area (VTA) dopamine neurons from rats chronically exposed to nicotine when used at a concentration of 1 µM.{51209} KT172 decreases production of 2-arachidonoyl glycerol (Item No. 62160) and subsequently reduces arachidonic acid (Item Nos. 90010
90010.1
10006607), prostaglandin E2 (PGE2; Item No. 14010), and PGD2 (Item No. 12010) in thioglycolate-stimulated peritoneal macrophages when administered at a dose of 5 mg/kg in mice.{30430}

Size	5 mg
Shipping	dry ice
CAS Number	1402612-56-9
Molecular Formula	C₂₈H₂₈N₄O₂
SMILES	O=C(N1N=NC(C2=CC=C(C3=C(OC)C=CC=C3)C=C2)=C1)N4C(CC5=CC=CC=C5)CCCC4
Molecular Weight	452,6
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.39
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.