24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol
24(S),25-epoxy Cholesterol is an oxysterol and the most abundant oxysterol in mouse ventral midbrain.{43943} It activates liver X receptors (LXRs)...
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NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels).{27789,25556} It can also activate voltage-gated Kv11.1 channels (hERG; IC50 = 1 µM), but does not, however, affect large conductance (BK/KCa1.1) channels.{27789,25556,27794} NS309 can modulate neuronal firing patterns by enhancing SK-mediated hyperpolarizing effects.{27789,25556} It is 730-fold (SK channels) and 7,400-fold (IK channels) more potent than 1-EBIO (Item No. 14575) and often used in conjunction with CyPPA (Item No. 15614) to distinguish between SK1 and SK3 subtypes.{27789,25556}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 mg, 5 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 18711-16-5 |
| Molecular formula | C8H4Cl2N2O2 |
| Smiles | O=C1/C(C2=CC=C(Cl)C(Cl)=C2N1)=NO, O=C1/C(C2=CC=C(Cl)C(Cl)=C2N1)=NO, O=C1/C(C2=CC=C(Cl)C(Cl)=C2N1)=NO |
| Molecular weight | 231 |
| Custom code | 2903.99 |
| Formulation | A solid |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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