Eliprodil

Eliprodil

CAT N°: 18398
Price:

From 55.00 46.75

N-Methyl-D-aspartate (NMDA) receptors are calcium permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. Eliprodil is a non-competitive NMDA receptor antagonist that inhibits neuronal calcium channel currents.{31071} It is selective for NR2B subunit-containing receptors (IC50 = 1 µM), displaying greater than 100-fold selectivity for NR2B over NR2A and NR2C subunits.{31074,31072} Eliprodil also avidly binds ?1 and ?2 sites (Kis = 0.013 and 0.63 µM, respectively).{31074} It is effective in vivo, blocking ischemia-induced neurodegeneration in the CA1 region of the hippocampus of gerbils subjected to bilateral carotid artery occlusion.{31071} Eliprodil can also have proarrhythmic actions in hearts under normal conditions.{31073}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • ?-?(4-?chlorophenyl)?-?4-?[(4-?fluorophenyl)?methyl]?-1-?piperidineethanol
  • Correlated keywords
    • 126613-29-4 127293-58-7 136634-88-3 SL820715 NR2B-NDMA neuronal calcium channel current Ca2+ NR-2B N-methyl-D-aspartate CA-1
  • Product Overview:
    N-Methyl-D-aspartate (NMDA) receptors are calcium permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. Eliprodil is a non-competitive NMDA receptor antagonist that inhibits neuronal calcium channel currents.{31071} It is selective for NR2B subunit-containing receptors (IC50 = 1 µM), displaying greater than 100-fold selectivity for NR2B over NR2A and NR2C subunits.{31074,31072} Eliprodil also avidly binds ?1 and ?2 sites (Kis = 0.013 and 0.63 µM, respectively).{31074} It is effective in vivo, blocking ischemia-induced neurodegeneration in the CA1 region of the hippocampus of gerbils subjected to bilateral carotid artery occlusion.{31071} Eliprodil can also have proarrhythmic actions in hearts under normal conditions.{31073}

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