Prostaglandin E Synthase (cytoso

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Prostaglandin E Synthase (cytosolic) Monoclonal Antibody (Clone JJ6)

Cat No: 18219

p23 is a highly conserved ubiquitous protein, known to have an important function as a co-chaperone for the Hsp90 chaperoning system.{16041} Studies have revealed that p23 is a small protein (18-25 kDa) with a simple structure.{16042,13980} p23 does n...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

co-chaperones cochaperones proteins antibodies antiserum antisera WB IP ELISA western blots EIA immunoprecipitation immunoblotting blotting enzyme-linked immunosorbent assays TEBP unactive EC 5.3.99.3 progesterone receptors complex 2

Product Overview:
p23 is a highly conserved ubiquitous protein, known to have an important function as a co-chaperone for the Hsp90 chaperoning system.{16041} Studies have revealed that p23 is a small protein (18-25 kDa) with a simple structure.{16042,13980} p23 does not have any structural homology with any other known proteins.{16041} p23 was first discovered as a part of the Hsp90-progesterone receptor complex along with Hsp70, p54, and p50.{16041} p23 is a phospho-protein, which is highly acidic and has an aspartic acid-rich C-terminal domain.{16041} Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase{16043}, the heme-regulated kinase HRI{16044}, Hsf1 transcription factor{16043}, aryl hydrocarbon receptor{16043}, telomerase{16045}, and Hepadnavirus reverse transcriptase.{16046} In spite of several years of study, the exact functional significance of p23 is still not clear.p23 is identical to cytosolic prostaglandin E synthase (cPGES), coverting to PGH2 to PGE2 downstream of COX-1.{8691} p23 is also thought to be involved in the adenosine triphosphate-mediated Hsp90 binding of client proteins.{16047} Since many Hsp90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis.{16048} Hsp90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.

Size	25 µg
Shipping	dry ice
Host	Mouse
Antigen	Recombinant human full length p23 protein
Clone	JJ6
Isotype	IgG1
Application(s)	WB,IP, and ELISA
Formulation	protein G affinity-purified mouse IgG at a concentration of 1 mg/ml in PBS, pH 7.2, containing 0.09% sodium azide and 50% glycerol
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.