Spermine

Spermine

CAT N°: 18041
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Spermine is an endogenous polyamine synthesized from the reaction of spermidine (Item No. 14918) with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis.{27553,29231} Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site.{29232} Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.{29233}

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