Spermine

Spermine

CAT N°: 18041

Spermine is an endogenous polyamine synthesized from the reaction of spermidine (Item No. 14918) with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis.{27553,29231} Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site.{29232} Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.{29233}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N1,N4-bis(3-aminopropyl)-1,4-butanediamine
  • Correlated keywords
    • 115-04-8 1127437-73-3 tetraaza tetradecane NSC268508 spermin neuroscience signal transduction ion channel pump blocker oxidative injury inflammation cell biology biochemical polyamine modulator neuroprotective anti-inflammation DNA damage natural 4,9-diazadodecane-1,12-diamine
  • Product Overview:
    Spermine is an endogenous polyamine synthesized from the reaction of spermidine (Item No. 14918) with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis.{27553,29231} Intracellular spermine blocks inward rectifying K+ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site.{29232} Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.{29233}

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