Trimethyl<wbr/>amine N-oxide

Trimethylamine N-oxide

CAT N°: 17354
Price:

From 48.00 40.80

Trimethylamine N-oxide (TMAO) is a metabolite of choline, phosphatidylcholine, and L-carnitine (Item No. 21489).{54307} It is formed by gut microbiota-mediated metabolism of choline, phosphatidylcholine, and L-carnitine to TMA followed by oxidation of TMA by flavin-containing monooxygenase 3 (FMO3) in the liver.{54307,54308,32692} Dietary administration of TMAO (0.12% w/w) increases renal tubulointerstitial fibrosis, collagen deposition, and Smad3 phosphorylation in mice and increases aortic lesion area in atherosclerosis-prone ApoE-/- mice.{54307,54309} Plasma levels of TMAO are elevated in patients with chronic kidney disease and decreased in patients with active, compared with inactive, ulcerative colitis.{54307,54308} Elevated plasma levels of TMAO are associated with increased risk of cardiovascular disease.{54309}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N,N-dimethyl-methanamine, N-oxide
  • Correlated keywords
    • 62637-93-8 7651-88-9 TMA flavin monooxygenase FMO Smad 3 ulcerative colitis NSC408426 triox
  • Product Overview:
    Trimethylamine N-oxide (TMAO) is a metabolite of choline, phosphatidylcholine, and L-carnitine (Item No. 21489).{54307} It is formed by gut microbiota-mediated metabolism of choline, phosphatidylcholine, and L-carnitine to TMA followed by oxidation of TMA by flavin-containing monooxygenase 3 (FMO3) in the liver.{54307,54308,32692} Dietary administration of TMAO (0.12% w/w) increases renal tubulointerstitial fibrosis, collagen deposition, and Smad3 phosphorylation in mice and increases aortic lesion area in atherosclerosis-prone ApoE-/- mice.{54307,54309} Plasma levels of TMAO are elevated in patients with chronic kidney disease and decreased in patients with active, compared with inactive, ulcerative colitis.{54307,54308} Elevated plasma levels of TMAO are associated with increased risk of cardiovascular disease.{54309}

We also advise you