Picropodo<wbr/>phyllotoxin

Picropodophyllotoxin

CAT N°: 17329
Price:

From 66.00 56.10

Picropodophyllotoxin (PPP) is a potent and selective inhibitor of the insulin-like growth factor-1 receptor (IGF-1R), blocking the phosphorylation of artificial substrates with an IC50 value of 6 nM.{33633} It does not block substrate phosphorylation by insulin receptor, EGFR, FGFR, or PDGFR. PPP inhibits IGF-1R autophosphorylation (IC50 = ~1 nM), causes cell cycle arrest in G2/M phase, and induces apoptosis.{33633,33634} It is orally active and causes complete tumor regression in xenografted and allografted mice.{33633} Presumably through its effect on IGF-1R, PPP reduces VEGF expression and suppresses choroidal neovascularization in vivo.{33631}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (5R,5aS,8aR,9R)-5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
  • Correlated keywords
    • 17434-18-3 AXL1717 IGF1R NSC36407 G-2
  • Product Overview:
    Picropodophyllotoxin (PPP) is a potent and selective inhibitor of the insulin-like growth factor-1 receptor (IGF-1R), blocking the phosphorylation of artificial substrates with an IC50 value of 6 nM.{33633} It does not block substrate phosphorylation by insulin receptor, EGFR, FGFR, or PDGFR. PPP inhibits IGF-1R autophosphorylation (IC50 = ~1 nM), causes cell cycle arrest in G2/M phase, and induces apoptosis.{33633,33634} It is orally active and causes complete tumor regression in xenografted and allografted mice.{33633} Presumably through its effect on IGF-1R, PPP reduces VEGF expression and suppresses choroidal neovascularization in vivo.{33631}

We also advise you