AZ 960

AZ 960

CAT N°: 16731
Price:

From €176.00 €149.60

Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F).{27171} Furthermore, constitutive activation of the JAK2 signaling pathway is associated with aggressive adult T cell leukemia/lymphoma.{27172} AZ 960 inhibits JAK2 with a Ki value of 0.45 nM in vitro.{27171} It can decrease STAT3/5 phosphorylation and inhibit cell proliferation in a SET-2 human megakaryoblastic cell line that is heterozygous for the JAK2 V617F mutation with a GI50 value of 33 nM.{27171} AZ 960 can also induce apoptosis in human T cell lymophotropic virus type 1-infected (IC50 = ~1 µM), which corresponds to a downregulation of phosphorylated forms of JAK2 and Bcl-2 family proteins.{27172}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5-fluoro-?2-?[[(1S)-?1-?(4-?fluorophenyl)?ethyl]?amino]?-?6-?[(5-?methyl-?1H-?pyrazol-?3-?yl)?amino]-3-pyridinecarbonitrile
  • Correlated keywords
    • Janus-associated kinase JAK2 myeloproliferative disease V617F mutation leukemia lymphoma ATL cancer signal transduction apoptosis Bcl-2 inhibit JAK 2 cytoplasmic cytoplasm tyrosine signaling cytokine growth factor receptor mutation valine phenylalanine aggressive adult T cell leukemia lymphoma in vitro STAT3/5 phosphorylation proliferation SET-2 two human megakaryoblastic line induce death lymphotropic virus type 1-infected downregulation downregulate down regulate family protein Bcl2 AZ960 SET2 AZ 960
  • Product Overview:
    Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F).{27171} Furthermore, constitutive activation of the JAK2 signaling pathway is associated with aggressive adult T cell leukemia/lymphoma.{27172} AZ 960 inhibits JAK2 with a Ki value of 0.45 nM in vitro.{27171} It can decrease STAT3/5 phosphorylation and inhibit cell proliferation in a SET-2 human megakaryoblastic cell line that is heterozygous for the JAK2 V617F mutation with a GI50 value of 33 nM.{27171} AZ 960 can also induce apoptosis in human T cell lymophotropic virus type 1-infected (IC50 = ~1 µM), which corresponds to a downregulation of phosphorylated forms of JAK2 and Bcl-2 family proteins.{27172}

We also advise you

Any project? Any challenge? We are in!
Contact us

Headquarters:
Parc d’activités du Pas du Lac
10 bis avenue Ampère

78180 Montigny le Bretonneux
France

Call us
Information
My account
Follow us

Copyright © 2024 BERTIN BIOREAGENT. All rights reserved | Terms & conditions

Secure payment
Subscribe to our newsletter