FTase Inhibitor II (trifluoro<wbr/>acetate salt)

FTase Inhibitor II (trifluoroacetate salt)

CAT N°: 16607
Price:

From 74.00 62.90

Farnesylation involves the utilization of farnesyl pyrophosphate (FPP), an intermediate in the mevalonate pathway, by farnesyltransferase (FTase) to add a lipid, farnesyl, to certain proteins.{26419,21707} This post-translational modification is crucial in allowing target proteins, including Ras, to associate with, and function at, membranes. FTase Inhibitor II is a cell-permeable analog of FPP that potently inhibits FTase (IC50 = 50-75 nM), preventing farnesylation of Ras.{27760} It does not inhibit geranylgeranyl transferase at similar concentrations (IC50 > 100 µM).{27760} FTase Inhibitor II displays no toxicity to untransformed cells but blocks Ras-mediated transformation of NIH 3T3 cells.{27760}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • N-[4-[[(2R)-2-amino-3-mercapto-1-oxopropyl]amino]benzoyl]-L-methionine, trifluoroacetate salt
  • Correlated keywords
    • 156707-43-6 313641-?99-?5 biochemical cancer inhibitor intracellular signaling signal transduction farnesyltransferase farnesyl transferase farnesylation utilization pyrophosphate FPP inhibit potent selective intermediate mevalonate pathway FTase lipid proteins post-translational posttranslational modification target Ras membrane cell-permeable analog block Ras-mediated transformation NIH 373 cell NIH373 H-Cys-4-Abz-Met-OH protein lipidation
  • Product Overview:
    Farnesylation involves the utilization of farnesyl pyrophosphate (FPP), an intermediate in the mevalonate pathway, by farnesyltransferase (FTase) to add a lipid, farnesyl, to certain proteins.{26419,21707} This post-translational modification is crucial in allowing target proteins, including Ras, to associate with, and function at, membranes. FTase Inhibitor II is a cell-permeable analog of FPP that potently inhibits FTase (IC50 = 50-75 nM), preventing farnesylation of Ras.{27760} It does not inhibit geranylgeranyl transferase at similar concentrations (IC50 > 100 µM).{27760} FTase Inhibitor II displays no toxicity to untransformed cells but blocks Ras-mediated transformation of NIH 3T3 cells.{27760}

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