VS-<wbr/>5584

VS-5584

CAT N°: 16294
Price:

From 48.00 40.80

Phosphatidylinositol 3-kinase (PI3K) signaling through Akt/PKB and the mammalian target of rapamycin (mTOR) controls gene expression related to cell proliferation, differentiation, and apoptosis. Increased activity of this pathway is important in many types of cancer. VS-5584 is a purine analog that inhibits mTOR (IC50 = 37 nM) and PI3K (IC50s = 16, 68, 25, and 42 nM for the ?, ?, ?, and ? isoforms, respectively) without relevant activity against more than 400 additional lipid and protein kinases.{27667} By inhibiting the phosphorylation of substrates downstream of PI3K and mTOR, VS-5584 demonstrates broad anti-proliferative sensitivity leading to tumor growth inhibition in human tumor models.{27667}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5-[8-methyl-9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]-2-pyrimidinamine
  • Correlated keywords
    • inhibitor mTOR PI3K antiproliferation antitumor cancer inhibit biochemical intracellular signaling kinase m-TOR anti-proliferation anti-tumor phosphatidylinositol 3-kinase Akt/PKB Akt PKB PI3K/mTOR mammalian target rapamycin gene expression cell differentiation apoptosis VS5584 purine analog ? ? ? ? isoform PI3K? PI3K? PI3K? PI3K? phosphorylation substrate downstream board sensitivity tumor growth human model
  • Product Overview:
    Phosphatidylinositol 3-kinase (PI3K) signaling through Akt/PKB and the mammalian target of rapamycin (mTOR) controls gene expression related to cell proliferation, differentiation, and apoptosis. Increased activity of this pathway is important in many types of cancer. VS-5584 is a purine analog that inhibits mTOR (IC50 = 37 nM) and PI3K (IC50s = 16, 68, 25, and 42 nM for the ?, ?, ?, and ? isoforms, respectively) without relevant activity against more than 400 additional lipid and protein kinases.{27667} By inhibiting the phosphorylation of substrates downstream of PI3K and mTOR, VS-5584 demonstrates broad anti-proliferative sensitivity leading to tumor growth inhibition in human tumor models.{27667}

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