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Prostaglandin F2? ethyl amide (PGF2?-NEt) is an analog of PGF2? in which the C-1 carboxyl group has been modified to an N-ethyl amide. PG esters have been shown to have ocular hypotensive activity.{8837} PG N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs.{8941} Although it has been claimed that PG ethyl amides are not converted to the free acids in vivo,{8941} studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 µg/g corneal tissue/hr.{9311} PGF2?-NEt would be expected to show the typical intraocular effects of PGF2? free acid, but with the much slower hydrolysis pharmacokinetics of the PG N-amides.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 5 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 54130-36-8 |
| Molecular formula | C22H39NO4 |
| Smiles | O[C@@H](CCCCC)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=CCCCC(N([H])CC)=O, O[C@@H](CCCCC)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=CCCCC(N([H])CC)=O, O[C@@H](CCCCC)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=CCCCC(N([H])CC)=O |
| Molecular weight | 381,6 |
| Custom code | 2937.50 |
| Formulation | A solution in methyl acetate |
| Purity | ≥98% |
| UNSPSC code | 12352100 |
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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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