Irbesartan

Irbesartan

CAT N°: 11952
Price:

66.00 56.10

Irbesartan is an antagonist of the angiotensin II type 1 (AT1) receptor (Ki = 1.3 nM).{21001} It is an insurmountable antagonist of AT1, as its antagonism cannot be overcome by increasing concentrations of angiotensin II.{21393} Irbesartan (3, 10, and 30 mg/kg) reduces blood pressure in stroke-prone spontaneously hypertensive rats and increases survival of SPSH rats fed a high-salt low-protein diet.{43281} It also reduces plaque formation, collagen content, as well as the increased expression of the AT1 receptor, PDGF-b, MCP-1, and VCAM-1 in a model of diabetes-induced atherosclerosis using apolipoprotein E (ApoE) knockout mice with diabetes induced by streptozotocin (STZ; Item No. 13104).{43280} Formulations containing irbesartan have been used, alone and in combination with diuretics, in the treatment of hypertension.

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