Ro 3306

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Ro 3306

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Cat No: 15149

Biochemicals - Kinase Inhibitors

Cyclin-dependent kinase 1 (Cdk1) complexes with different cyclins, with the cyclin determining substrate specificity. Ro 3306 is a cell-permeable, reversible inhibitor of Cdk1, showing preference for Cdk1/cyclin B1 (Ki = 35 nM) over Cdk1/cyclin A (Ki =...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5Z-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone

Correlated keywords:

inhibitors cells cycles cancers apoptosis inhibits inhibitions cyclin dependent cyclin-dependent kinases 1 one CDKs Cdk1 Cdk-1 one 1 Ro-3306 Ros 3306 Ro3306 cell-permeable permeable reversible Cdk1/B1 B 1 B-1 Cdk2 two 2 Cdk-2 serum glucocorticoid induces induced kinases SGKs G2/M G-2 G2 G M phases acute myeloid leukemia AMLs nutlins 3 three nutlin-3 proteins Cdk1/A cycling

Product Overview:
Cyclin-dependent kinase 1 (Cdk1) complexes with different cyclins, with the cyclin determining substrate specificity. Ro 3306 is a cell-permeable, reversible inhibitor of Cdk1, showing preference for Cdk1/cyclin B1 (Ki = 35 nM) over Cdk1/cyclin A (Ki = 110 nM), two CDK complexes which regulate cell cycling.{24139} It also inhibits Cdk2 (Ki = 340 nM), PKCδ (Ki = 318 nM), and serum- and glucocorticoid-induce kinase (Ki = 497 nM) but not Cdk4.{24139} Through its effects on Cdk1, Ro 3306 reversibly arrests proliferating cells at the G2/M phase border, allowing cell synchronization without the use of microtubule poisons.{24140} Prolonged treatment of cells with Ro 3306 induces apoptosis and this can be augmented in acute myeloid leukemia cells by stimulating p53 activity with nutlin-3.{24141}

Size	1 mg
Shipping	dry ice
CAS Number	872573-93-8
Molecular Formula	C₁₈H₁₃N₃OS₂
SMILES	O=C1/C(SC(NCC2=CC=CS2)=N1)=C/C3=CC=C(N=CC=C4)C4=C3
Molecular Weight	351,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2930.90
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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