Oltipraz

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Oltipraz

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Cat No: 15118

Biochemicals - Small Molecule Activators

Oltipraz, originally identified as an antischistosomiasis agent, is a potent anticarcinogen in a variety of animal models of cancer at concentrations of ~200 mg/kg.{24177} It is an effective inducer of phase I and II detoxifying enzymes, including glu...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-methyl-5-(2-pyrazinyl)-3H-1,2-dithiole-3-thione

Correlated keywords:

anticarcinogen anti carcinogen anti-carcinogen cancers phases I detoxifying enzymes II detoxifying detox enzymes glutathiones S transferases S-tranferases GSTs UDP-glucuronosyltransferases UGTs UDP glucuronosyltransferases NADs NAD(P)H:quinone oxidoreductase NQO1 microsomal epoxide hydrolase aflatoxins aldehydes reductase transcriptions factors nuclears factors E2–related 2 Nrf2 E2 related antioxidants anti-oxidants oxidants responses elements ARE CYP2B constitutive androstane CARs NSCs 347901 NSC-347901 NSC347901 RPs RP35972 35972 RP-35972 transcriptions antischistosomiasis anti-schistosomiasis schistosomiasis

Product Overview:
Oltipraz, originally identified as an antischistosomiasis agent, is a potent anticarcinogen in a variety of animal models of cancer at concentrations of ~200 mg/kg.{24177} It is an effective inducer of phase I and II detoxifying enzymes, including glutathione S-transferases, UDP-glucuronosyltransferases, NAD(P)H:quinone oxidoreductase, microsomal epoxide hydrolase, and aflatoxin aldehyde reductase.{24177,24178} Induction of these metabolic enzymes by oltipraz has been linked to the transcription factor nuclear factor E2-related factor 2 and its activation of the antioxidant response element.{24177} In mice, oltipraz at 150 mg/kg can also induce expression of CYP2B, a gene regulated by the constitutive androstane receptor, a transcription factor important in the detoxification of endobiotic and xenobiotic substances.{24179}

Size	100 mg
Shipping	dry ice
CAS Number	64224-21-1
Molecular Formula	C₈H₆N₂S₃
SMILES	CC1=C(SSC1=S)C2=NC=CN=C2
Molecular Weight	226,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.59
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.