Quinacrine (hydrochloride hydrat

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Quinacrine (hydrochloride hydrate)

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Cat No: 15041

Quinacrine is an acridine compound with diverse biological activities that has also been used as a stain for DNA and RNA in fixed cells and for fluorescent tracking of acidic vesicles, such as lysosomes, in live cells.{23969,23970,23759,23972} It has ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N4-(6-chloro-2-methoxyacridin-9-yl)-N1,N1-diethylpentane-1,4-diamine, dihydrochloride hydrate

Correlated keywords:

69-05-6 83-89-6 133347-98-5 inhibitors inhibits inhibitions receptors antagonists ions channels blockers prions proteins infectious diseases HCl antiprotozoal anti-protozoal anti protozoal agents aldehydes oxidases riboflavins binds binding binders P-glycoprotein glycoproteins phospholipases A2 quincrine mepacrine misfolding blocks prevents voltage-dependent sodium channels voltage dependent Na+ Na antagonists riboflavin-binding P

Product Overview:
Quinacrine is an acridine compound with diverse biological activities that has also been used as a stain for DNA and RNA in fixed cells and for fluorescent tracking of acidic vesicles, such as lysosomes, in live cells.{23969,23970,23759,23972} It has anti-protozoal properties, potently prevents misfolding of prion protein (EC50 = 0.3 μM), blocks voltage-dependent sodium channels (IC50 = 3.3 μM), and inhibits aldehyde oxidase (IC50 = 3.3 μM).{23969,23970,23759,23972} Quinacrine is also an effective riboflavin antagonist, associating with the riboflavin-binding protein (Ki = 6.7 μM), and an inhibitor of P-glycoprotein (EC50 = 14.4 μM).{23968,23971} At much higher doses, quinacrine inhibits phospholipase A2 activity.{23974,12506} Quinacrine binds to nucleic acids and has been used in fixed cells to stain DNA and RNA with excitation/emission maxima of 436/525 nm, respectively.{38900} In live cells, it is taken up into acidic vesicles, such as lysosomes, and can be used to for long-term imaging with an excitation of 458 nm and emission in the 470-580 nm range.{38901}

Size	100 mg
Shipping	dry ice
Molecular Formula	C₂₃H₃₀ClN₃O • 2HCl [XH₂O]
SMILES	ClC1=CC=C2C(NC(C)CCCN(CC)CC)=C3C(C=CC(OC)=C3)=NC2=C1.Cl.Cl.O
Molecular Weight	472,9
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.