SGC-CBP30

SGC-CBP30

CAT N°: 14469
Price:

From 165.00 140.25

cAMP-responsive element-binding protein binding protein (CREBBP) and E1A-associated protein p300 (EP300) are transcriptional co-activators. Each contains a bromodomain, which recognizes acetylated lysine residues on target proteins. SGC-CBP30 is a potent inhibitor of CREBBP and EP300 bromodomains (IC50s = 21-69 and 38 nM, respectively).{26201} Developed by the Structural Genomics Consortium (SGC), this compound displays over 40-fold selectivity for CREBBP over BRD4(1) and is functional in cells.

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-4-isoxazolyl)-1-[(2S)-2-(4-morpholinyl)propyl]-1H-benzimidazole
  • Correlated keywords
    • inhibitors epigenetics acetyls readers genes regulations CREBBPs cAMP-responsive cAMPs responsive element-bindings elements bindings proteins SGC CBP30 CBP 30 thirty SGCCBP30 EP300s bromodomains bromo domains bromo-domains Structural Genomics Consortium compounds selectivity BRD4(1) BRD4-1 BRD4s 1s ones BRD41s functional functionality functions cells
  • Product Overview:
    cAMP-responsive element-binding protein binding protein (CREBBP) and E1A-associated protein p300 (EP300) are transcriptional co-activators. Each contains a bromodomain, which recognizes acetylated lysine residues on target proteins. SGC-CBP30 is a potent inhibitor of CREBBP and EP300 bromodomains (IC50s = 21-69 and 38 nM, respectively).{26201} Developed by the Structural Genomics Consortium (SGC), this compound displays over 40-fold selectivity for CREBBP over BRD4(1) and is functional in cells.

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