Caspase-<wbr/>3/7 Inhibitor I

Caspase-3/7 Inhibitor I

CAT N°: 14464
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From 176.00 149.60

Caspase-3/7 inhibitor I is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (Ki(app) = 60 nM; IC50 = 120 nM) and caspase-7 (Ki(app) = 170 nM).{8115} It is a weaker inhibitor of caspase-9 (Ki(app) = 3.1 ?M) and caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8 (Ki(app)s ?25 ?M).{8115,8929} Caspase-3/7 inhibitor I inhibits apoptosis in camptothecin-treated Jurkat cells (IC50 = ~50 µM) and in chondrocytes (44% inhibition at 10 µM and 98% inhibition at 50 µM).{8929} The basis for the unique selectivity of this compound for caspases 3 and 7 involves the recognition of three distinct hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue.{8115}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 5-[[2-(methoxymethyl)-1-pyrrolidinyl]sulfonyl]-1H-indole-2,3-dione
  • Correlated keywords
    • inhibitors caspase-3 caspase-7 caspases 3 7 inhibits inhibitions potent reversible isatins sulfonamide-based sulfonamides 9 1 2 4 6 8 apoptosis camptothecin-treated camptothecin treated treats Jurkat cells condrocytes hydrophobic residues S2 catalytic cysteines I
  • Product Overview:
    Caspase-3/7 inhibitor I is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (Ki(app) = 60 nM; IC50 = 120 nM) and caspase-7 (Ki(app) = 170 nM).{8115} It is a weaker inhibitor of caspase-9 (Ki(app) = 3.1 ?M) and caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8 (Ki(app)s ?25 ?M).{8115,8929} Caspase-3/7 inhibitor I inhibits apoptosis in camptothecin-treated Jurkat cells (IC50 = ~50 µM) and in chondrocytes (44% inhibition at 10 µM and 98% inhibition at 50 µM).{8929} The basis for the unique selectivity of this compound for caspases 3 and 7 involves the recognition of three distinct hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue.{8115}

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