Diacerein

Diacerein

CAT N°: 11710
Price:

From 66.00 56.10

Diacerein is a prodrug form of the anthraquinone derivative rhein (Item No. 17345).{65008} It inhibits RANKL- and IL-1?-induced differentiation of RAW 264.7 cells into osteoclasts when used at a concentration of 20 µg/ml.{25635} Diacerein (20 µg/ml) reduces levels of interleukin-1?-converting enzyme (ICE), also known as caspase-1, as well as IL-1?, and IL-18 in the superficial zone of human osteoarthritic cartilage explants.{65009} It decreases carrageenan-, dextran-, or zymosan-induced paw edema in rats when administered at a dose of 100 mg/kg.{65010}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid
  • Correlated keywords
    • natural products arthritis inhibitors inflammation intracellular signaling NF-kB inhibits inhibitions IL-1? IL1? IL 1? beta .beta. b? MMPs MMP1 MMP13 MMP-1 MMP-13 1 13 metalloproteases collagen affrecan diacetoxyanthraquinone-2-carboxylic acid 4,5-diacetylrhein artrodar diacerhein diacetylrhein fisiodar SF 277 SF277 SF-277 RAW264.7
  • Product Overview:
    Diacerein is a prodrug form of the anthraquinone derivative rhein (Item No. 17345).{65008} It inhibits RANKL- and IL-1?-induced differentiation of RAW 264.7 cells into osteoclasts when used at a concentration of 20 µg/ml.{25635} Diacerein (20 µg/ml) reduces levels of interleukin-1?-converting enzyme (ICE), also known as caspase-1, as well as IL-1?, and IL-18 in the superficial zone of human osteoarthritic cartilage explants.{65009} It decreases carrageenan-, dextran-, or zymosan-induced paw edema in rats when administered at a dose of 100 mg/kg.{65010}

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