GW 6471

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GW 6471

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Cat No: 11697

Biochemicals - Receptor Pharmacology

The peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor that regulates the expression of genes involved in fatty acid metabolism, lipoprotein synthesis and metabolism, and inflammation.{7654,14916,20898} GW 6471 is an antagonist ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[(2S)-2-[[(1Z)-1-methyl-3-oxo-3-[4-(trifluoromethyl)phenyl]-1-propen-1-yl]amino]-3-[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]propyl]-propanamide

Correlated keywords:

436159-64-7 antagonists nuclears receptors PPARs peroxisomes proliferator-activated proliferator activated PPAR? PPARalpha PPAR.alpha. PPARa PPAR-? PPAR-alpha PPAR-.alpha. PPAR-a ? alpha .alpha. GWs GW6471 a GW-5471 6471 displacement coactivators co-activators co activators promotes co-repressor reprssors proteins corepressor nuclear N-CoR NCoR N Cor cell-free cells free lysate whole antagonism

Product Overview:
The peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor that regulates the expression of genes involved in fatty acid metabolism, lipoprotein synthesis and metabolism, and inflammation.{7654,14916,20898} GW 6471 is an antagonist of PPARα (IC50 = 240 nM).{23912} It drives the displacement of coactivators from PPARα and promotes the recruitment of co-repressor proteins like nuclear co-repressor.{23912} GW 6471 is used in cell-free, cell lysate, and whole cell systems to examine the impact of PPARα antagonism.{23911,23910,23913}

Size	1 mg
Shipping	dry ice
CAS Number	880635-03-0
Molecular Formula	C₃₅H₃₆F₃N₃O₄
SMILES	CC1=C(N=C(C2=CC=CC=C2)O1)CCOC3=CC=C(C[C@@H](CNC(CC)=O)N/C(C)=C\C(C4=CC=C(C(F)(F)F)C=C4)=O)C=C3
Molecular Weight	619,7
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.