Histone H2A (Xenopus, recombinant)
Histone H2A (Xenopus, recombinant)
Histone H2A is a core histone that forms a dimer with histone H2B.{46631} Two histone H2A/H2B dimers form an octameric...
€818.00
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From €122.00 €103.70
From €122.00 €103.70
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors.{14963} AG-879 is a tyrphostin compound that inhibits nerve growth factor (NGF)-dependent TrkA tyrosine phosphorylation in PC-12 cells (IC50 = ~40 ?M), HER2-ErbB2 kinase in several breast and ovarian cancer cell lines (IC50 = ~0.5 ?M), and the VEGF receptor FLK1 (IC50 = ~1 ?M).{15153} Additionally, AG-879 inhibits the activation of ETK with an IC50 value of ~5 nM, which blocks tyrosine phosphorylation of PAK1, suppressing Ras transformation of NIH 3T3 fibroblasts.{19455} AG-879 has also been shown to suppress IL-6-induced tyrosine phosphorylation of STAT3 (IC50 = 15 ?M) in schwannoma cells.{19454}
Territorial Availability: Available through Bertin Technologies only in France
| Size | 10 mg, 25 mg, 5 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 148741-30-4 |
| Molecular formula | C18H24N2OS |
| Smiles | CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(/C=C(C(N)=S)C#N)=C1, CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(/C=C(C(N)=S)C#N)=C1, CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(/C=C(C(N)=S)C#N)=C1, CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(/C=C(C(N)=S)C#N)=C1 |
| Molecular weight | 316,5 |
| Custom code | 2907.19 |
| Formulation | A crystalline solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
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