AG-<wbr/>879

AG-879

CAT N°: 10793
Price:

122.00 103.70

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors.{14963} AG-879 is a tyrphostin compound that inhibits nerve growth factor (NGF)-dependent TrkA tyrosine phosphorylation in PC-12 cells (IC50 = ~40 ?M), HER2-ErbB2 kinase in several breast and ovarian cancer cell lines (IC50 = ~0.5 ?M), and the VEGF receptor FLK1 (IC50 = ~1 ?M).{15153} Additionally, AG-879 inhibits the activation of ETK with an IC50 value of ~5 nM, which blocks tyrosine phosphorylation of PAK1, suppressing Ras transformation of NIH 3T3 fibroblasts.{19455} AG-879 has also been shown to suppress IL-6-induced tyrosine phosphorylation of STAT3 (IC50 = 15 ?M) in schwannoma cells.{19454}

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