SB-242084 (hydro<wbr>chloride)

SB-242084 (hydrochloride)

CAT N°: 10096
Price:

From 71.00 60.35

Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that activates specific receptors located primarily in the gut and central nervous system. SB-242084 is an antagonist of the 5-HT2C receptor (pKi = 9.0), with at least 100-fold more selectivity over other 5-HT, dopamine, or adrenergic receptors.{18221,18225} In vivo, it is brain penetrant and has significant anxiolytic activity, without sedative, proconvulsant, or hyperphagic properties.{18221} SB-242084 has been used extensively in animal research to evaluate, for example, 5-HT2C receptor agonists and neurotransmitter receptor interactions in mice.{18222,18223,18224}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • 6-chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxamide, dihydrochloride
  • Correlated keywords
    • 181632-25-7 serotonins 5-hydroxytryptamines 5-HT neurotransmitters neuroscience receptors gut central nervous system antagonists 5-HT2C dopamine adrenergic receptors brain anxiolytic neurochemistry CNS Antigens HLA-SB Antigens HLA-PL Antigens HLA-DP HLA-SB Antigens HLA-PL Antigens HLA-DP Antigens HLA SB Antigens HLA PL Antigens HLA DP Antigens HLA-SB HLA-PL HLA-DP
  • Product Overview:
    Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter that activates specific receptors located primarily in the gut and central nervous system. SB-242084 is an antagonist of the 5-HT2C receptor (pKi = 9.0), with at least 100-fold more selectivity over other 5-HT, dopamine, or adrenergic receptors.{18221,18225} In vivo, it is brain penetrant and has significant anxiolytic activity, without sedative, proconvulsant, or hyperphagic properties.{18221} SB-242084 has been used extensively in animal research to evaluate, for example, 5-HT2C receptor agonists and neurotransmitter receptor interactions in mice.{18222,18223,18224}

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