Ac-YVAD-CHO

Ac-YVAD-CHO

CAT N°: 10016
Price:

85.00 72.25

Ac-YVAD-CHO is an inhibitor of caspase-1/interleukin-1? converting enzyme (ICE; Ki = 0.76 nM) and an acetylated form of the caspase-1 inhibitor YVAD-CHO (Item No. 27420).{58835,7777} It is selective for caspase-1 over caspase-4, -5, -8, -9, and -10 (Kis = 163-970 nM), as well as over caspase-2, -3, -6, and -7 (Kis = >10,000 nM for all).{7777} It inhibits activation of caspase-1 and IL-1? in a cell-free assay using LPS-treated THP-1 cell homogenates when used at a concentration of 5 µM.{58836} Ac-YVAD-CHO (12.5 µmol/kg) reduces pancreatic levels of IL-18 and serum levels of IL-1?, as well as reduces pyroptosis of pancreatic cells, in a mouse model of cerulein-induced acute pancreatitis but does not decrease pancreatic expression of NOD-like receptor protein 3 (NLRP3).{58837} It increases susceptibility to lethal E. coli infection but prevents LPS-induced death in C3H/HeN mice when administered at doses of 5 and 10 mg/kg, respectively.{58838}

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