Capsazepine

Capsazepine

CAT N°: 10007518
Price:

48.00 40.80

Transient receptor potential vanilloid type 1 (TRPV1) is a member of the transient receptor potential (TRP) family that is activated or sensitized by a variety of endogenous stimuli as a result of tissue injury and inflammation. TRPV1 is upregulated during inflammation and plays a role in the perception of pain.{13323,14052} Capsazepine is a competitive antagonist of transient receptor potential vanilloid type 1 (TRPV1) which blocks the capsaicin-induced uptake of Ca2+ in neonatal rat dorsal root ganglia with an IC50 of 0.42 µM and Chinese hamster ovary cells with an IC50 of 17 nM.{13323,14051} It does not block acid- or heat-induced activation of TRPV1 and may block receptors other than TRPV1.{14053,14054}

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