TMEM16A Rabbit Monoclonal Antibo

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TMEM16A Rabbit Monoclonal Antibody

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Cat No: 35619

Transmembrane protein 16A (TMEM16A), also known as anoctamin-1 (ANO1) or discovered on gastrointestinal stromal tumors 1 (DOG1), is a calcium-activated chloride channel (CaCC) encoded by ANO1 that has roles in several cellular functions, including pro...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

ANO DOG TMEM16 TMEM 16A IL4 IL6 IL13 interleukin ERK NF?B

Product Overview:
Transmembrane protein 16A (TMEM16A), also known as anoctamin-1 (ANO1) or discovered on gastrointestinal stromal tumors 1 (DOG1), is a calcium-activated chloride channel (CaCC) encoded by ANO1 that has roles in several cellular functions, including proliferation, survival, and migration, as well as cell secretion and airway and vascular smooth muscle contraction.{57860} It exists as a homodimer where each monomer is composed of cytosolic N- and C-terminal domains and a transmembrane domain that has ten membrane-spanning segments, which contain the calcium-binding sites and form the ion channel pore.{57861,57862} It is expressed by a variety of cells, including epithelial, vascular endothelial, neuronal, smooth muscle, and myocardial cells, and localizes to the plasma membrane.{57860,57863} TMEM16A levels are increased by several stimuli, including IL-4, IL-6, and IL-13, as well as EGF, angiotensin II, and LPS, in a cell-dependent manner.{57860} TMEM16A activation is induced by increased intracellular calcium levels, which occurs via calcium influx through calcium-permeable ion channels or calcium release from the endoplasmic reticulum.{57864} It induces chloride ion transport, the direction of which is dependent on the membrane potential and intracellular chloride concentration, which modulates numerous cellular processes, including membrane depolarization and EGFR, ERK1/2, and NF-κB signaling pathways.{57860,57863} Intratumoral TMEM16A protein expression is increased relative to adjacent normal tissue and associated with lymph node metastasis and reduced overall survival in patients with gastric cancer.{57865} Cayman's TMEM16A Rabbit Monoclonal Antibody can be used for immunohistochemistry (IHC).

Size	100 µl
Shipping	dry ice
Host	Rabbit
Antigen	Peptide corresponding to the internal region of TMEM16A
Clone	RM440
Isotype	IgG
Application(s)	IHC
Formulation	100 µl of protein A-affinity purified monoclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

Technical File

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.