FHIT (human, recombinant)

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Cat No: 35510

Proteins - Enzymes

Fragile histidine triad diadenosine triphosphatase (FHIT) is a hydrolase and tumor suppressor.{60935,60936,60937} It contains a His-x-His-x-His motif that hydrolyzes diadenosine triphosphate (Ap3A), as well as Ap4A and ATP.{60935} FHIT is expressed in...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

Escherichia FRA 3B FRA3

Product Overview:
Fragile histidine triad diadenosine triphosphatase (FHIT) is a hydrolase and tumor suppressor.{60935,60936,60937} It contains a His-x-His-x-His motif that hydrolyzes diadenosine triphosphate (Ap3A), as well as Ap4A and ATP.{60935} FHIT is expressed in spleen, brain, kidney, lung, and liver and localizes to the plasma membrane, nucleus, mitochondria, and cytoplasm.{60938,60939,60940} It is involved in tumor suppression and genome stability.{60936} Overexpression of FHIT induces apoptosis in lung cancer cells and reduces tumor growth in lung cancer mouse xenograft models.{60941} Homozygous or heterozygous loss of FHIT expression is prevalent in several cancers, and the FHIT gene contains a common fragile site, FRA3B, that is a translocation breakpoint associated with hereditary kidney cancer.{60937} Cayman’s FHIT (human, recombinant) protein consists of 153 amino acids and has a calculated molecular weight of 17.7 kDa. By SDS-PAGE, under reducing conditions, the apparent molecular mass of the protein is 18 kDa.

Size	100 µg
Shipping	dry ice
Formulation	Lyophilized from sterile 50 mM Tris, pH 8.0, with 10% glycerol
Purity	≥85% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

Technical File

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.