JNJ-16259685

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JNJ-16259685

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Cat No: 35377

Biochemicals - Receptor Pharmacology

JNJ-16259685 is an antagonist of metabotropic glutamate receptor 1a (mGluR1a; Ki = 0.34 nM in CHO(dHFr-) cell membranes expressing the rat receptor).{63296} It is selective for mGluR1a over mGluR5, -2, -3, -4, and -6, as well as a panel of neurotransm...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)(cis-4-methoxycyclohexyl)-methanone

Correlated keywords:

JNJ16259685 mGluR mGluR2 mGluR3 mGluR4 mGluR6

Product Overview:
JNJ-16259685 is an antagonist of metabotropic glutamate receptor 1a (mGluR1a; Ki = 0.34 nM in CHO(dHFr-) cell membranes expressing the rat receptor).{63296} It is selective for mGluR1a over mGluR5, -2, -3, -4, and -6, as well as a panel of neurotransmitter receptors, ion channels, and transporters, at 10 µM. JNJ-16259685 inhibits glutamate-induced inositol phosphate accumulation in primary rat cerebellar neurons with an IC50 value of 1.73 nM. It increases drinking in the Vogel punished drinking task, indicating anxiolytic-like activity, when administered at doses of 2.5, 5, or 10 mg/kg.{63297}

Size	1 mg
Shipping	dry ice
CAS Number	409345-29-5
Molecular Formula	C₂₀H₂₃NO₃
SMILES	CO[C@@H]1CC[C@H](C(C2=CC(C=C(CCCO3)C3=N4)=C4C=C2)=O)CC1
Molecular Weight	325,4
Formulation	A solid
Purity	≥95%
Custom Code	2933.49
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.