BI-3406

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BI-3406

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Cat No: 35261

Biochemicals - More Biochemicals

BI-3406 is an inhibitor of the protein-protein interaction between K-Ras and the guanine nucleotide exchange factor son of sevenless homolog 1 (SOS1; IC50 = 5 nM).{62502} It selectively disrupts the protein-protein interaction between K-RasG12C or K-R...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]-7-methoxy-2-methyl-6-[[(3S)-tetrahydro-3-furanyl]oxy]-4-quinazolinamine

Correlated keywords:

BI3406 dld1 A-549 NCIH23 NCIH358 NCIH520

Product Overview:
BI-3406 is an inhibitor of the protein-protein interaction between K-Ras and the guanine nucleotide exchange factor son of sevenless homolog 1 (SOS1; IC50 = 5 nM).{62502} It selectively disrupts the protein-protein interaction between K-RasG12C or K-RasG12D with SOS1 over SOS2, and it is selective over 321 kinases in a panel at 10 µM but does inhibit PLK4, BMPR2, and LRRK2 activity by greater than 50%. BI-3406 inhibits the growth of DLD-1, A549, NCI H23, and NCI H358 cells expressing mutant K-Ras (IC50s = 16-52 nM) but not NCI H520 and A375 cells expressing wild-type K-Ras. BI-3406 (12 or 50 mg/kg, twice per day) reduces tumor growth in an MIA PaCa-2 mouse xenograft model.

Size	1 mg
Shipping	dry ice
CAS Number	2230836-55-0
Molecular Formula	C₂₃H₂₅F₃N₄O₃
SMILES	C[C@H](C1=CC(C(F)(F)F)=CC(N)=C1)NC2=NC(C)=NC3=C2C=C(O[C@H]4CCOC4)C(OC)=C3
Molecular Weight	462,5
Formulation	A solid
Purity	≥98%
Custom Code	2933.49
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.