Sardomozide (hydrochloride)

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Cat No: 34901

Biochemicals - More Biochemicals

Sardomozide is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC), an enzyme involved in polyamine biosynthesis (IC50 = 0.005 µM for the rat liver enzyme).{61691} It is selective for SAMDC over diamine oxidase (DAO; IC50 = 18 µM for the rat sm...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-[4-(aminoiminomethyl)-2,3-dihydro-1H-inden-1-ylidene]-hydrazinecarboximidamide, dihydrochloride

Correlated keywords:

149400-88-4 CGP48664 SAM-486A SAM486-A SAM-486-A T-24 L-1210 PM-1 SK-MEL24 SKMEL-24 SKMEL24

Product Overview:
Sardomozide is an inhibitor of S-adenosylmethionine decarboxylase (SAMDC), an enzyme involved in polyamine biosynthesis (IC50 = 0.005 µM for the rat liver enzyme).{61691} It is selective for SAMDC over diamine oxidase (DAO; IC50 = 18 µM for the rat small intestine enzyme). Sardomozide inhibits the proliferation of T24 bladder cancer cells (IC50 = 0.71 µM). It decreases intracellular levels of spermidine and spermine and increases intracellular putrescine levels in L1210 murine leukemia cells when used at a concentration of 3 µM.{61692} Sardomozide (0.2 and 0.4 µM) inhibits HIV-1 replication in PM1 cells.{61693} It reduces tumor growth in a SK-MEL-24 melanoma mouse xenograft model when administered at doses of 0.5 and 5 mg/kg.{61692}

Size	5 mg
Shipping	dry ice
CAS Number	138794-73-7
Molecular Formula	C₁₁H₁₄N₆ • 2HCl
SMILES	N=C(N/N=C1C2=CC=CC(C(N)=N)=C2CC/1)N.Cl.Cl
Molecular Weight	303,2
Formulation	A solid
Purity	≥95%
Custom Code	2933.99
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.