N-Desbutyl Dronedarone (hydrochl

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N-Desbutyl Dronedarone (hydrochloride)

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Cat No: 34888

Biochemicals - Small Molecule Inhibitors

N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone (Item No. 9000543).{58755,58756,58757} It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.{58758}...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[2-butyl-3-[4-[3-(butylamino)propoxy]benzoyl]-5-benzofuranyl]-methanesulfonamide, monohydrochloride

Correlated keywords:

141626-35-9 NDBD DBDron anti arrhythmic cyto chrome P 450 TR? 1 TR? 1 CYP 2J2 H9 c2 debutyldronedarone desbutyldronedarone SR35021 SR 35021

Product Overview:
N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone (Item No. 9000543).{58755,58756,58757} It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.{58758} N-Desbutyl dronedarone inhibits the binding of 3,3',5-triiodo-L-thyronine (T3; Item No. 16028) to the thyroid hormone receptors TRα1 and TRβ1 (IC50s = 59 and 280 µM for the chicken and human receptors, respectively).{58755} It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide hydrolase-mediated formation of 14,15-DHET from 14,15-EET (IC50s = 1.59 and 2.73 µM, respectively, in cell-free assays).{58756} N-Desbutyl dronedarone decreases intracellular ATP levels in H9c2 rat cardiomyocytes (IC50 = 1.07 µM) and inhibits mitochondrial complex I, also known as NADH dehydrogenase, and mitochondrial complex II, also known as succinate dehydrogenase, activities in isolated rat heart mitochondria (IC50s = 11.94 and 24.54 µM, respectively).{58757}

Size	1 mg
Shipping	dry ice
CAS Number	197431-02-0
Molecular Formula	C₂₇H₃₆N₂O₅S • HCl
SMILES	O=C(C1=C(CCCC)OC2=CC=C(NS(C)(=O)=O)C=C21)C3=CC=C(C=C3)OCCCNCCCC.Cl
Molecular Weight	537,1
Formulation	A solid
Purity	≥95%
Custom Code	2935.90
UNSPSC code	12352100

Technical File

MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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