Isoproterenol-d7 (hydrochloride)

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Isoproterenol-d₇ (hydrochloride)

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Cat No: 34704

Biochemicals - Isotopically Labeled Standards

Isoproterenol-d7 is intended for use as an internal standard for the quantification of isoproterenol (Item No. 15592) by GC- or LC-MS. Isoproterenol is an agonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 224 and 458 nM, respectively)....

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-(1-hydroxy-2-((propan-2-yl-d7)amino)ethyl)benzene-1,2-diol, monohydrochloride

Correlated keywords:

2517584-03-9 ?1AR ?2AR ?3AR NSC 37745 89747 NSC37745 NSC89747 LCMS GCMS deuterated deuterium

Product Overview:
Isoproterenol-d7 is intended for use as an internal standard for the quantification of isoproterenol (Item No. 15592) by GC- or LC-MS. Isoproterenol is an agonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 224 and 458 nM, respectively).{25395} It is selective for β1- and β2-ARs over β3-ARs (Ki = 1,570 nM). Isoproterenol inhibits contractions in isolated field-stimulated rat vas deferens (EC50 = 45.6 nM).{25571} In vivo, isoproterenol (0.33 mg/kg) decreases blood pressure and increases water intake in nephrectomized rats.{58617} It reduces blood pressure and increases heart rate in renal hypertensive rabbits.{58618} Isoproterenol inhibits histamine-induced bronchospasms in anesthetized dogs.{58619} Formulations containing isoproterenol have been used in the treatment of bradydysrhythmias and to improve breathing during anesthesia.

Size	1 mg
Shipping	dry ice
CAS Number	2517584-04-0
Molecular Formula	C₁₁H₁₀D₇NO₃ • HCl
SMILES	[2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])NCC(C1=CC(O)=C(C=C1)O)O.Cl
Molecular Weight	254,8
Formulation	A solid
Purity	≥99% deuterated forms (d1-d7)
Custom Code	3822.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.