AMK (hydrochloride)

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AMK (hydrochloride)

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Cat No: 34688

Biochemicals - Ox Stress Reagents

AMK is an active metabolite of the neurohormone melatonin (Item No. 14427).{63121,63122,63123,63124} It is formed from melatonin via the metabolic intermediate AFMK (Item No. 10005254) that is then deformylated by catalase or formamidase.{63125,12284}...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[3-(2-amino-5-methoxyphenyl)-3-oxopropyl]-acetamide, monohydrochloride

Correlated keywords:

52450-39-2 PGE PGD COX2 2647

Product Overview:
AMK is an active metabolite of the neurohormone melatonin (Item No. 14427).{63121,63122,63123,63124} It is formed from melatonin via the metabolic intermediate AFMK (Item No. 10005254) that is then deformylated by catalase or formamidase.{63125,12284} AMK scavenges singlet oxygen in vitro when used at a concentration of 200 µM.{63121} It inhibits the epinephrine- and arachidonic acid-induced production of prostaglandin E2 (PGE2; Item No. 14010) and PGD2 (Item No. 12010) in ovine seminal vesicle microsomes in a concentration- and time-dependent manner, as well as LPS-induced increases in COX-2 levels in RAW 264.7 macrophages when used at a concentration of 500 µM.{63122,63123} AMK (20 mg/kg) decreases MPTP-induced increases in lipid peroxidation in the cytosol and mitochondria from substantia nigra and striatum in a mouse model of MPTP-induced Parkinson’s disease.{63124}

Size	1 mg
Shipping	dry ice
CAS Number	1215711-91-3
Molecular Formula	C₁₂H₁₆N₂O₃ • HCl
SMILES	O=C(C)NCCC(C1=CC(OC)=CC=C1N)=O.Cl
Molecular Weight	272,7
Formulation	A solid
Purity	≥95%
Custom Code	2924.29
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.