Verbenalin

Verbenalin

CAT N°: 34663
Price:

From 48.00 40.80

Verbenalin is an iridoid glucoside that has been found in V. officinalis and has diverse biological activities.{61605,61606,61607} It inhibits the activities of COX-1 and COX-2 by 37 and 48%, respectively, when used at a concentration of 258 µM.{61606} Verbenalin (129 µM) inhibits proliferation of AGS gastric, SF-268 CNS, HCT116 colon, NCI H460 lung, and MCF-7 breast cancer cells. It reduces carrageenan-induced paw edema, as well as ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014), in mice.{61607} Verbenalin (5 and 10 mg/kg) reduces increases in malondialdehyde (MDA) levels and the production of reactive oxygen species (ROS) in brain mitochondria isolated from, as well as decreases infarct volume and neurological deficits in, a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{61605}

Territorial Availability: Available through Bertin Technologies only in France

  • Synonyms
    • (1S,4aS,7S,7aR)-1-(?-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-7-methyl-5-oxo-cyclopenta[c]pyran-4-carboxylic acid, methyl ester
  • Correlated keywords
    • 1391-15-7 Verbenaloside NSC118055 COX1 COX2 Verbena SF268 HCT 116 H 460 MCF7
  • Product Overview:
    Verbenalin is an iridoid glucoside that has been found in V. officinalis and has diverse biological activities.{61605,61606,61607} It inhibits the activities of COX-1 and COX-2 by 37 and 48%, respectively, when used at a concentration of 258 µM.{61606} Verbenalin (129 µM) inhibits proliferation of AGS gastric, SF-268 CNS, HCT116 colon, NCI H460 lung, and MCF-7 breast cancer cells. It reduces carrageenan-induced paw edema, as well as ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014), in mice.{61607} Verbenalin (5 and 10 mg/kg) reduces increases in malondialdehyde (MDA) levels and the production of reactive oxygen species (ROS) in brain mitochondria isolated from, as well as decreases infarct volume and neurological deficits in, a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{61605}

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