€542.00 €460.70
IL-17 receptor A (IL-17RA), also known as CD217, is a cytokine receptor that has roles in immunity and inflammation.{61785} It is composed of two extracellular fibronectin III-like domains that form the ligand-binding and receptor-dimerization domain, a transmembrane domain, an SEF/IL-17R (SEFIR) domain, a TIR-like loop (TILL), and a C/EBP? activation domain (CBAD). IL-17RA is ubiquitously expressed and localizes to the plasma membrane.{61786} It also exists as a soluble form that results from alternative splicing of IL17RA pre-mRNA. IL-17RA is involved in autoimmunity, neutrophil recruitment, and host defense.{61785} It forms a complex with IL-17RB, IL-17RC, or IL-17RE, each of which have varying affinities for the homodimeric ligands IL-17A, IL-17E, and IL-17F, and the IL-17A/IL-17F heterodimer.{61785,61787} Knockout of Il17ra increases mortality in mice infected with T. cruzi.{61788} In contrast, Il17ra-/- mice are protected against the development of collagen-induced arthritis.{61789} Mutations in IL17RA have been found in patients with chronic mucocutaneous candidiasis, a disease characterized by recurrent or persistent commensal Candida infections.{61790} Cayman’s Interleukin-17RA/CD217 Extracellular Domain (human, recombinant) protein can be used for binding assays. This protein is a disulfide-linked homodimer. The reduced monomer, composed of IL-17RA fused to AVI-tagged IgG1 Fc at its C-terminus, has a calculated molecular weight of 62 kDa. As a result of glycosylation, the monomer migrates at approximately 95 kDa by SDS-PAGE under reducing conditions.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 100 µg |
|---|---|
| Shipping | dry ice |
| Molecular weight | 0 |
| Formulation | 8 mM Phosphate buffer, pH 7.4, with 110 mM sodium chloride, 2.2 mM potassium chloride, and 20% glycerol |
| Purity | ≥80% estimated by SDS-PAGE |
| Custom code | 3504.00 |
| UNSPSC code | 12352204 |
Cayman Chemical’s mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.
Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.
Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.
Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.
Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009
Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.
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