7-ethyl Camptothecin

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Cat No: 34607

Biochemicals - Small Molecule Inhibitors

7-ethyl Camptothecin is a derivative of camptothecin (Item No. 11694) and an anticancer agent.{63212,63213} It inhibits wild-type but not Gly533 mutant topoisomerase I in RPMI-8402 and CPT-K5 cells, respectively (IC50s = 5.48 and >2,500 nM, respective...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(4S)-4,11-diethyl-4-hydroxy-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Correlated keywords:

SN22 anti cancer Gly 533 RPMI8402 CPTK5 SN38 MM-46 L-1210 P-388 ethylcamptothecin

Product Overview:
7-ethyl Camptothecin is a derivative of camptothecin (Item No. 11694) and an anticancer agent.{63212,63213} It inhibits wild-type but not Gly533 mutant topoisomerase I in RPMI-8402 and CPT-K5 cells, respectively (IC50s = 5.48 and >2,500 nM, respectively).{63212} 7-ethyl Camptothecin is cytotoxic to ADJ/PC6 SN-38-sensitive and PC6/SN2-5H2 SN-38-resistant cells (IC50s = 0.85 and 2.98 nM, respectively). In vivo, 7-ethyl camptothecin (0.25-3 mg/kg per day) increases survival in Ehrlich, MM46, Meth A, L1210, P388, and B16/F10 mouse ascites tumor models.{63213}

Size	100 mg
Shipping	dry ice
CAS Number	78287-27-1
Molecular Formula	C₂₂H₂₀N₂O₄
SMILES	O=C1N2C(C3=NC4=CC=CC=C4C(CC)=C3C2)=CC5=C1COC([C@]5(O)CC)=O
Molecular Weight	376,4
Formulation	A solid
Purity	≥98%
Custom Code	2939.79
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.