Etiocholanolone

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Etiocholanolone

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Cat No: 34501

Biochemicals - Ion Channel Modulation

Etiocholanolone is an androgenically inactive metabolite of testosterone and androstenedione and the 5β epimer of androsterone (Item No. 15872).{57692,35430} It increases the frequency of long channel openings and potentiates GABA-induced chloride cur...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(5?)-3?-hydroxy-androstan-17-one

Correlated keywords:

Aetiocholanolon NSC50908 HEK-293 IL1 interleukin isoandrosterone iso-androsterone

Product Overview:
Etiocholanolone is an androgenically inactive metabolite of testosterone and androstenedione and the 5β epimer of androsterone (Item No. 15872).{57692,35430} It increases the frequency of long channel openings and potentiates GABA-induced chloride currents in HEK293 cells expressing rat α1β2γ2L subunit-containing GABAA receptors when used at a concentration of 10 µM.{57693} Etiocholanolone is protective against seizures induced by 6 Hz electroshock or pentylenetetrazol (PTZ; ED50s = 76.9 and 139 mg/kg, respectively).{57694} It is also pyretic in an IL-1-dependent manner, inducing increases in body temperature in rhesus macaques but not squirrel monkeys that lack testosterone and androstenedione metabolizing enzymes.{57695}

Size	5 mg
Shipping	dry ice
CAS Number	53-42-9
Molecular Formula	C₁₉H₃₀O₂
SMILES	C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C[C@@H](CC2)O)([H])[C@@]4([H])[C@](CC3)(C(CC4)=O)C
Molecular Weight	290,4
Formulation	A solid
Purity	≥98%
Custom Code	2937.29
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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