Tiliroside

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Tiliroside

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Cat No: 34493

Biochemicals - Lipids

Tiliroside is a polyketide synthase-derived flavonoid glycoside that has been found in Q. ilex and has diverse biological activities.{58639,42158,58640,58641,58642} It inhibits carbonic anhydrase VII (CAVII; Ki = 4.6 nM), but not CAI, CAII, CAIV, or C...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[[6-O-[(2E)-3-(4-hydroxyphenyl)-1-oxo-2-propen-1-yl]-?-D-glucopyranosyl]oxy]-4H-1-benzopyran-4-one

Correlated keywords:

26187-98-4 29317-69-9 72691-80-6 74742-81-7 93860-34-5 104641-16-9 152447-76-2 162120-54-9 457897-25-5 1214252-63-7 trans-Tiliroside Potengriffioside A Quercus Hep G2 COLO205

Product Overview:
Tiliroside is a polyketide synthase-derived flavonoid glycoside that has been found in Q. ilex and has diverse biological activities.{58639,42158,58640,58641,58642} It inhibits carbonic anhydrase VII (CAVII; Ki = 4.6 nM), but not CAI, CAII, CAIV, or CAXII (Kis = >10, >10, 5.46, and 0.134 µM, respectively), in a cell-free assay.{42158} Tiliroside scavenges DPPH (Item No. 14805) and superoxide radicals (IC50s = 12.8 and 42 µM, respectively) and is cytotoxic to Jurkat, HepG2, and COLO 205 cells (IC50s = 11.6, 14.3, and 55.4 µM, respectively).{58640} It reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) with an ID50 value of 0.357 mg/ear.{58641} Tiliroside (100 mg/kg) decreases triglyceride accumulation in the liver and skeletal muscle in high-fat diet-fed KKAy diabetic mice.{58642}

Size	5 mg
Shipping	dry ice
CAS Number	20316-62-5
Molecular Formula	C₃₀H₂₆O₁₃
SMILES	O=C(C(O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)COC(/C=C/C2=CC=C(C=C2)O)=O)=C(C3=CC=C(C=C3)O)OC4=CC(O)=C5)C4=C5O
Molecular Weight	594,5
Formulation	A solid
Purity	≥98%
Custom Code	2938.90
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.