8-Oxycoptisine

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8-Oxycoptisine

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Cat No: 34472

Biochemicals - Natural Products

8-Oxycoptisine is an isoquinoline alkaloid that has been found in Coptis chinensis and has anticancer and gastroprotective activities.{61590,61591,61592} It is an active metabolite of coptisine (Item No. 28424) formed by gut microbiota.{61590} 8-Oxyco...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

6,7-dihydro-4H-bis[1,3]benzodioxolo[5,6-a:4?,5?-g]quinolizin-4-one

Correlated keywords:

oxy oxo coptisine anti cancer gastro protective NCIN87 Caco2 SKOV 3 HCT15 Pgp multi drug UC

Product Overview:
8-Oxycoptisine is an isoquinoline alkaloid that has been found in Coptis chinensis and has anticancer and gastroprotective activities.{61590,61591,61592} It is an active metabolite of coptisine (Item No. 28424) formed by gut microbiota.{61590} 8-Oxycoptisine is cytotoxic against NCI-N87 gastric, but not Caco-2 colon, cancer cells (IC50s = 20.31 and >100 µM, respectively).{61591} It reverses resistance to paclitaxel (Item No. 10461) in non-multidrug-resistant SKOV3 cells, as well as in HCT-15 cells, which endogenously express high levels of P-glycoprotein (P-gp), with EC50 values of 0.3 and 0.5 ng/ml, respectively.{61592} It reduces colonic shortening and inflammatory cell infiltration in a mouse model of ulcerative colitis induced by dextran sulfate (DSS; Item No. 23250) when administered at doses of 50 or 100 mg/kg.{61590}

Size	1 mg
Shipping	dry ice
CAS Number	19716-61-1
Molecular Formula	C₁₉H₁₃NO₅
SMILES	O=C1C2=C(C=C3C4=CC5=C(C=C4CCN13)OCO5)C=CC6=C2OCO6
Molecular Weight	335,3
Formulation	A solid
Purity	≥98%
Custom Code	2933.79
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.