VU0238429

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VU0238429

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Cat No: 34411

Biochemicals - Receptor Pharmacology

VU0238429 is a positive allosteric modulator of M5 muscarinic acetylcholine receptors (mAChRs; EC50 = 1.16 µM in a calcium mobilization assay).{60969} It is selective for M5 mAChRs over M1, M2, M3, and M4 mAChRs in CHO cells expressing the human recep...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione

Correlated keywords:

VU-0238429 ML-129 HY12157 mAChR 5HT 5HT2A MK801 GS39783

Product Overview:
VU0238429 is a positive allosteric modulator of M5 muscarinic acetylcholine receptors (mAChRs; EC50 = 1.16 µM in a calcium mobilization assay).{60969} It is selective for M5 mAChRs over M1, M2, M3, and M4 mAChRs in CHO cells expressing the human receptors (EC50s = >30 µM for all in calcium mobilization assays). VU0238429 (10 mg/kg) reduces head-twitch behavior induced by the serotonin (5-HT) receptor subtype 5-HT2A agonist DOI in mice.{60970} It reverses MK-801-induced memory deficits in the novel object recognition test in mice when administered alone or in combination with the GABAB receptor positive allosteric modulator GS-39783 (Item No. 29482).

Size	5 mg
Shipping	dry ice
CAS Number	1160247-92-6
Molecular Formula	C₁₇H₁₂F₃NO₄
SMILES	O=C1C(N(CC2=CC=C(C=C2)OC)C3=CC=C(C=C13)OC(F)(F)F)=O
Molecular Weight	351,3
Formulation	A solid
Purity	≥98%
Custom Code	2934.99
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.