Levistolide A

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Levistolide A

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Cat No: 34386

Biochemicals - More Biochemicals

Levistolide A is a phthalide that has been found in Angelica tenuissima and has diverse biological activities.{63245,63246,63247,63248} It inhibits phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) and A23187-induced histamine release from HMC-...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(1Z,5S,5aS,8Z,10bS,10cS)-1,8-dibutylidene-5,5a,6,7,8,10b-hexahydro-1H-5,10c-ethanonaphtho[1,2-c:7,8-c?]difuran-3,10-dione

Correlated keywords:

89708-23-6 HMC1 HCT-116 APP-PS-1

Product Overview:
Levistolide A is a phthalide that has been found in Angelica tenuissima and has diverse biological activities.{63245,63246,63247,63248} It inhibits phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) and A23187-induced histamine release from HMC-1 human mast cell leukemia cells when used at a concentration of 10 µM.{63245} Levistolide A (100 µM) induces the production of reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, and apoptosis in HCT116 colon cancer cells.{63246} It prevents ethanol-induced gastric ulcers in rats when administered at a dose of 10 mg/kg.{63247} Levistolide A (2 mg/kg) decreases aggregation of amyloid-β in brain and improves spatial and learning memory in the APP/PS1 transgenic mouse model of Alzheimer’s disease.{63248}

Size	1 mg
Shipping	dry ice
CAS Number	88182-33-6
Molecular Formula	C₂₄H₂₈O₄
SMILES	CCC/C=C1[C@@]23[C@@]4([H])C5=C(CC[C@@]4([H])[C@H](CC3)C=C2C(O/1)=O)/C(OC5=O)=C/CCC
Molecular Weight	380,5
Formulation	A solid
Purity	≥98%
Custom Code	2932.20
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.