Chlorzoxazone-d3

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Chlorzoxazone-d₃

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Cat No: 34237

Biochemicals - Ion Channel Modulation

Chlorzoxazone-d3 is intended for use as an internal standard for the quantification of chlorzoxazone (Item No. 18869) by GC- or LC-MS. Chlorzoxazone is a centrally acting muscle relaxant and an activator of small and intermediate conductance calcium-a...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-chloro-2(3H)-benzoxazolone-4,6,7-d3

Correlated keywords:

deuterated deuterium GCMS LCMS NSC 26189 NSC26189

Product Overview:
Chlorzoxazone-d3 is intended for use as an internal standard for the quantification of chlorzoxazone (Item No. 18869) by GC- or LC-MS. Chlorzoxazone is a centrally acting muscle relaxant and an activator of small and intermediate conductance calcium-activated potassium channels (EC50s = 87 and 98 µM for KCa2.2 and KCa3.1, respectively).{27789,23031} In vivo, chlorzoxazone (10 mg/kg) decreases alcohol, but not water, intake in a dose-dependent manner and reduces the propensity for rapid initial alcohol intake in rats with intermittent, but not continuous, access to alcohol.{43334} Formulations containing chlorzoxazone have been used in the treatment of pain and stiffness caused by muscle spasm.

Size	500 µg
Shipping	dry ice
CAS Number	1185173-60-7
Molecular Formula	C₇HClD₃NO₂
SMILES	O=C1OC2=C([2H])C([2H])=C(Cl)C([2H])=C2N1
Molecular Weight	172,6
Formulation	A solid
Purity	≥99% deuterated forms (d1-d3)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.