Phosphoramide Mustard (cyclohexy

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Phosphoramide Mustard (cyclohexylammonium salt)

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Cat No: 34078

Biochemicals - More Biochemicals

Phosphoramide mustard is an alkylating agent and active metabolite of cyclophosphamide (Item No. 13849).{58492} It is formed from cyclophosphamide via the ring-opened tautomer of the cytochrome P450 (CYP) isoform-formed intermediate 4-hydroxycyclophos...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N,N-bis(2-chloroethyl)-phosphorodiamidic acid, compd. with cyclohexanamine

Correlated keywords:

10159-53-2 87040-44-6 131636-50-5 NSC69945 Phosphamide Asta 5317

Product Overview:
Phosphoramide mustard is an alkylating agent and active metabolite of cyclophosphamide (Item No. 13849).{58492} It is formed from cyclophosphamide via the ring-opened tautomer of the cytochrome P450 (CYP) isoform-formed intermediate 4-hydroxycyclophosphamide.{58494} Phosphoramide mustard induces DNA crosslinking, alkylates guanine in DNA, and increases the production of covalent DNA-protein conjugates in, and is cytotoxic to, HT-1080 human fibrosarcoma cells in a concentration-dependent manner. It is toxic to adult mice and teratogenic to embryos when administered to pregnant dams at a dose of 154 mg/kg on day 11 of gestation.{58493}

Size	1 mg
Shipping	dry ice
CAS Number	1566-15-0
Molecular Formula	C₄H₁₁Cl₂N₂O₂P • C₆H₁₃N
SMILES	O=P(N)(N(CCCl)CCCl)O.NC1CCCCC1
Molecular Weight	320,2
Formulation	A solid
Purity	≥95%
Custom Code	2929.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.