Shanzhiside methyl ester

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Cat No: 34047

Biochemicals - Natural Products

Shanzhiside methyl ester is an iridoid glycoside that has been found in L. rotata and has anti-inflammatory and antinociceptive activities.{60632,60633} It is a glucagon-like peptide 1 receptor (GLP-1R) agonist.{60632} Shanzhiside methyl ester (10 µM)...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-(?-D-glucopyranosyloxy)-1S,4aS,5R,6,7S,7aS-hexahydro-5,7-dihydroxy-7-methyl-cyclopenta[c]pyran-4-carboxylic acid, methyl ester

Correlated keywords:

Shanziside Shanzhizide Sanshiside antiinflammatory anti-nociceptive Lamiophlomis GLP1R IL8

Product Overview:
Shanzhiside methyl ester is an iridoid glycoside that has been found in L. rotata and has anti-inflammatory and antinociceptive activities.{60632,60633} It is a glucagon-like peptide 1 receptor (GLP-1R) agonist.{60632} Shanzhiside methyl ester (10 µM) inhibits the release of myeloperoxidase (MPO) and elastase from isolated rat neutrophils activated by N-Formyl-Met-Leu-Phe (fMLF; Item No. 21495).{60633} It also inhibits LPS-induced increases in the release of IL-8 and leukotriene B4 (LTB4; Item Nos. 20110
10007240) from isolated rat neutrophils when used at a concentration of 10 µM. Shanzhiside methyl ester reduces L5/L6 spinal nerve ligation-induced mechanical allodynia in rats (ED50 = 40.4 µg/animal), an effect that can be reversed by the GLP-1R antagonist exendin (9-39).{60632}

Size	1 mg
Shipping	dry ice
CAS Number	64421-28-9
Molecular Formula	C₁₇H₂₆O₁₁
SMILES	COC(C1=CO[C@H]([C@@]2([H])[C@]1([H])[C@@H](C[C@@]2(O)C)O)O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)=O
Molecular Weight	406,4
Formulation	A solid
Purity	≥98%
Custom Code	2938.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.