?-Conotoxin ImI (trifluoroacetat

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?-Conotoxin ImI (trifluoroacetate salt)

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Cat No: 34022

Biochemicals - Ion Channel Modulation

α-Conotoxin ImI is a conotoxin that has been found in C. imperialis and has receptor antagonist and anticancer activities.{62392} It is a peptide antagonist of homomeric α7 nicotinic acetylcholine receptors (nAChRs; IC50 = 220 nM). α-Conotoxin ImI is ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

cyclic (2?8),(3?12)-bis(disulfide) glycyl-L-cysteinyl-L-cysteinyl-L-seryl-L-?-aspartyl-L-prolyl-L-arginyl-L-cysteinyl-L-alanyl-L-tryptophyl-L-arginyl-L-cysteinamide, trifluoroacetate salt

Correlated keywords:

156467-85-5 conus ?CTx MCF7

Product Overview:
α-Conotoxin ImI is a conotoxin that has been found in C. imperialis and has receptor antagonist and anticancer activities.{62392} It is a peptide antagonist of homomeric α7 nicotinic acetylcholine receptors (nAChRs; IC50 = 220 nM). α-Conotoxin ImI is selective for α7 nAChRs over α2β2, α3β2, α4β2, α2β4, α3β4, α4β4, and α1β1γδ subunit-containing nAChRs at 5 µM but does inhibit homomeric α9 nAChRs (IC50 = 1,800 nM). Administration of paclitaxel (Item No. 10461) in micelles containing α-conotoxin ImI decreases tumor growth in an MCF-7 mouse xenograft model.{62393} Intracerebroventricular, but not intraperitoneal, administration of α-conotoxin ImI (20 nmol/animal) induces seizures in rats.{62394}

Size	1 mg
Shipping	dry ice
Molecular Formula	C₅₂H₇₈N₂₀O₁₅S₄ • XCF₃COOH
SMILES	O=C(N[C@H](C(N[C@@H](CSSC[C@@H]1NC([C@H](CSSC[C@@H](NC([C@@H](NC([C@@]2([H])N(CCC2)C([C@@H](NC([C@@H](NC1=O)CO)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)C(N[C@H](C(N3)=O)C)=O)NC(CN)=O)=O)C(N)=O)=O)CCCNC(N)=N)[C@@H]3CC4=CNC5=CC=CC=C45.FC(F)(C(O)=O)F
Molecular Weight	1351,6
Formulation	A solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.