Brevilin A

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Brevilin A

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Cat No: 33993

Biochemicals - Kinase Inhibitors

Brevilin A is a sesquiterpene lactone that has been found in C. minima and has anticancer activity.{60488} It is an inhibitor of STAT3 signaling (IC50 = 10.6 µM in A549R cells) that inhibits the tyrosine kinase activity of the JAK1, JAK2, JAK3, and JA...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2Z)-2-methyl-2-butenoic acid, 2,3S,3aR,4S,4aR,5,7aR,8R,9,9aR-decahydro-3,4a,8-trimethyl-2,5-dioxoazuleno[6,5-b]furan-4-yl ester

Correlated keywords:

79297-80-6 Angeloylplenolin Angeloyl- plenolin prenolin anti-cancer Centipeda STAT-3 A549-R JAK-1 2 3 4 JH-1 Hep-G2 A-875 CT-26 LC3II

Product Overview:
Brevilin A is a sesquiterpene lactone that has been found in C. minima and has anticancer activity.{60488} It is an inhibitor of STAT3 signaling (IC50 = 10.6 µM in A549R cells) that inhibits the tyrosine kinase activity of the JAK1, JAK2, JAK3, and JAK4 JH1 subunit (IC50s = 11.2, 8.4, 10.2, and 11.9 µM, respectively).{60489} It inhibits proliferation of a variety of cancer cells, including A549 lung, HepG2 liver, HeLa cervical, A875 melanoma, and CT26 mouse colon carcinoma cells in a concentration-dependent manner.{60488} Brevilin A (1-4 µg/ml) decreases the mitochondrial membrane potential, induces apoptosis, and increases the level of reactive oxygen species (ROS) in CT26 cells. It also induces autophagosome formation in CT26 cells, an effect that can be blocked by the PI3K inhibitor 3-methyladenine (Item No. 13242). Brevilin A (5 mg/kg per day) increases intratumor expression of the autophagy marker LC3-II and reduces tumor growth in a murine CT26 colon cancer model.

Size	1 mg
Shipping	dry ice
CAS Number	16503-32-5
Molecular Formula	C₂₀H₂₆O₅
SMILES	C/C=C(C)\C(O[C@H]1[C@@]2([H])[C@@](OC([C@H]2C)=O)([H])C[C@H]([C@@]3([H])[C@]1(C(C=C3)=O)C)C)=O
Molecular Weight	346,4
Formulation	A solid
Purity	≥98%
Custom Code	2932.20
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.