EGTA - C14H24N2O10 - Bertin Bioreagent

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EGTA

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Cat No: 33963

Biochemicals - More Biochemicals

EGTA is an aminopolycarboxylic acid chelating agent.{60534} It is selective for calcium over magnesium with Kapp values for calcium ranging from 6.93 to 10.7 x 105 M-1 in various buffers at pH 6.8 and 20°C. EGTA (5 mM) inhibits apoptosis induced by th...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3,12-bis(carboxymethyl)-6,9-dioxa-3,12-diazatetradecanedioic acid

Correlated keywords:

33382-61-5 56618-01-0 Chelest-GEA EBONTA EDGA NSC615010 Tetra-acetic aminopoly-carboxylic Lac-Z

Product Overview:
EGTA is an aminopolycarboxylic acid chelating agent.{60534} It is selective for calcium over magnesium with Kapp values for calcium ranging from 6.93 to 10.7 x 105 M-1 in various buffers at pH 6.8 and 20°C. EGTA (5 mM) inhibits apoptosis induced by the sarcoplasmic/endoplasmic Ca2+-ATPase (SERCA) inhibitor thapsigargin (Item No. 10522) in isolated rat thymocytes.{60535} It has been used as an irrigation agent to remove the smear layer from the pulp canal wall on extracted human teeth.{60536} Intranasal administration of EGTA enhances adenovirus-mediated gene transfer of LacZ to the trachea and main bronchi in mice by 8-fold.{60537}

Size	25 g
Shipping	dry ice
CAS Number	67-42-5
Molecular Formula	C₁₄H₂₄N₂O₁₀
SMILES	O=C(CN(CCOCCOCCN(CC(O)=O)CC(O)=O)CC(O)=O)O
Molecular Weight	380,4
Formulation	A solid
Custom Code	2922.50
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.