Uvaol

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Uvaol

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Cat No: 33915

Biochemicals - Natural Products

Uvaol is a pentacyclic triterpenoid that has been found in olive (O. europaea) leaves and has diverse biological activities.{61428,46858,61429,61430} It induces cell cycle arrest at the G0/G1 phase and inhibits proliferation of MCF-7 human breast canc...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

urs-12-ene-3?,28-diol

Correlated keywords:

1315333-03-9 Uvalol NSC159627 Olea MCF7

Product Overview:
Uvaol is a pentacyclic triterpenoid that has been found in olive (O. europaea) leaves and has diverse biological activities.{61428,46858,61429,61430} It induces cell cycle arrest at the G0/G1 phase and inhibits proliferation of MCF-7 human breast cancer cells in a concentration-dependent manner.{46858} Uvaol (10 µM) prevents hydrogen peroxide-induced DNA damage in the same cells. It induces relaxation of phenylephrine- or potassium chloride-precontracted aortic rings isolated from spontaneously hypertensive rats when used at a concentration of 100 µM.{61429} Uvaol (200 and 500 µmol/kg) inhibits ovalbumin-induced bronchoalveolar lavage fluid (BALF) eosinophil infiltration in an ovalbumin-sensitized mouse model of allergic asthma.{61430}

Size	10 mg
Shipping	dry ice
CAS Number	545-46-0
Molecular Formula	C₃₀H₅₀O₂
SMILES	C[C@@]12C([C@@]3([H])[C@@](CC2)(CC[C@H]([C@@H]3C)C)CO)=CC[C@@]4([H])[C@]1(CC[C@]5([H])[C@@]4(CC[C@@H](C5(C)C)O)C)C
Molecular Weight	442,7
Formulation	A solid
Purity	≥95%
Custom Code	2906.19
UNSPSC code	12352100

Technical File

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.