Trimeprazine (tartrate)

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Cat No: 33891

Biochemicals - Receptor Pharmacology

Trimeprazine is a histamine H1 receptor antagonist (Ki = 0.72 nM in a radioligand binding assay).{23214} It is selective for the histamine H1 receptor over muscarinic acetylcholine receptors (mAChRs; Ki = 38 nM in a radioligand binding assay). Trimepr...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N,N,?-trimethyl-10H-phenothiazine-10-propanamine, 2R,3R-dihydroxybutanedioate

Correlated keywords:

84-96-8 14101-45-2 41375-66-0 71769-49-8 1236363-00-0 SARSCoV2 CoV2 SARSCoV VeroE6 ACh NSC17475 panectyl repeltin temaril 16 theralene vallergan vanectyl

Product Overview:
Trimeprazine is a histamine H1 receptor antagonist (Ki = 0.72 nM in a radioligand binding assay).{23214} It is selective for the histamine H1 receptor over muscarinic acetylcholine receptors (mAChRs; Ki = 38 nM in a radioligand binding assay). Trimeprazine inhibits anti-IgE-induced histamine release from isolated human lung fragments (IC50 = 19 nM) but induces histamine release with a 50% release concentration (RC50) of 1.03 µM.{52786} It reduces severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in SARS-CoV-2-infected Vero E6 cells (EC50 = 1.76 µM) with a 50% cytotoxic concentration (CC50) value of 19.73 µM.{62432} Formulations containing trimeprazine have been used in the treatment of allergic pruritis and motion sickness.

Size	50 mg
Shipping	dry ice
CAS Number	4330-99-8
Molecular Formula	C₁₈H₂₂N₂S • 1/2C₄H₆O₆
SMILES	CN(C)CC(C)CN1C2=CC=CC=C2SC3=CC=CC=C31.OC([C@H](O)[C@@H](O)C(O)=O)=O
Molecular Weight	373,5
Formulation	A solid
Purity	≥98%
Custom Code	2934.30
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.