Plecanatide (acetate)

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Cat No: 33878

Biochemicals - Receptor Pharmacology

Plecanatide is a peptide agonist of the guanylate cyclase C receptor.{62429} It stimulates cGMP production in T84 colon cancer cells (EC50 = 170 nM). Plecanatide (10 ppm in the diet) reduces increases in the number of neoplastic colon epithelial cells...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-asparaginyl-L-?-aspartyl-L-?-glutamyl-L-cysteinyl-L-?-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-leucine, cyclic (4?12),(7?15)-bis(disulfide), monoacetate

Correlated keywords:

467426-54-6 Ki67 trinitrobenzene-sulfonic SP304 Trulance

Product Overview:
Plecanatide is a peptide agonist of the guanylate cyclase C receptor.{62429} It stimulates cGMP production in T84 colon cancer cells (EC50 = 170 nM). Plecanatide (10 ppm in the diet) reduces increases in the number of neoplastic colon epithelial cells expressing Ki-67, a marker of cell proliferation, induced by dextran sulfate (DSS; Item No. 23250) in cancer-prone Apc+/Min-FCCC mice.{62430} It suppresses trinitrobenzenesulfonic acid-induced increases in abdominal contractions in a rat model of visceral hypersensitivity when administered at doses of 0.01 and 0.05 mg/kg.{62431} Formulations containing plecanatide have been used in the treatment of chronic idiopathic constipation.

Size	1 mg
Shipping	dry ice
Molecular Formula	C₆₅H₁₀₄N₁₈O₂₆S₄ • C₂H₄O₂
SMILES	O=C([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC([C@@H](N)CC(N)=O)=O)=O)N[C@](CSSC[C@@](NC([C@@H](NC([C@@H](NC1=O)C(C)C)=O)C)=O)([H])C(N[C@@]([H])([C@H](O)C)C(NC2)=O)=O)([H])C(N[C@H](C(N[C@@](C(N[C@](CSSC[C@@H](C(N[C@H](C(O)=O)CC(C)C)=O)NC2=O)([H])C(N[C@H](C(N[C@H]
Molecular Weight	1741,9
Formulation	A solid
Purity	≥98%
Custom Code	2934.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.