Gossypetin

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Gossypetin

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Cat No: 33840

Biochemicals - Natural Products

Gossypetin is a flavonoid that has been found in H. sabdariffa and has diverse biological activities.{60456,60457,60458} It inhibits the MAP2K kinases MKK3 and MKK6 in a concentration-dependent manner, as well as induces apoptosis and cell cycle arres...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxy-4H-1-benzopyran-4-one

Correlated keywords:

Hibiscus MAP-2K MKK-3 6 KYSE450 KYSE510 Hydroxyquercetin Articulatidin CI75750 CI-75750 Equisporol

Product Overview:
Gossypetin is a flavonoid that has been found in H. sabdariffa and has diverse biological activities.{60456,60457,60458} It inhibits the MAP2K kinases MKK3 and MKK6 in a concentration-dependent manner, as well as induces apoptosis and cell cycle arrest at the G2 phase in KYSE-450 and KYSE-510 esophageal cancer cells when used at a concentration of 20 µM.{60456} Gossypetin scavenges DPPH (Item No. 14805) radicals and inhibits copper-induced lipid peroxidation in cell-free assays.{60457} It reduces high-fat diet-induced increases in serum cholesterol, triglycerides, and LDL-cholesterol levels, as well as decreases aortic extracellular lipid and foam cell deposits in a rabbit model of atherosclerosis when administered at a dose of 10 mg/kg.{60458}

Size	1 mg
Shipping	dry ice
CAS Number	489-35-0
Molecular Formula	C₁₅H₁₀O₈
SMILES	OC(C=C(C(OC1=C(C(O)=CC(O)=C1O)C2=O)=C2O)C=C3)=C3O
Molecular Weight	318,2
Formulation	A solid
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.